Lebrun Labs Nonanimal Alternative Toxicology Testing
There Is a Better Way
Animal Testing Is No Longer the Only Option
Lebrun Labs has developed OECD-validated, regulatory-accepted nonanimal test methods that deliver faster results, lower costs, and zero animal use -- without sacrificing scientific rigor.
Why the Industry Is Moving Away from Animal Testing
Animal Testing Is Outdated
Traditional Draize and LD50 tests use animals, produce variable results, and face increasing regulatory and public pressure worldwide.
Slow and Expensive
In-vivo studies take weeks and cost tens of thousands of dollars per compound, slowing your product development pipeline.
Regulatory Uncertainty
Many animal methods are no longer accepted by the EU and are under review in the US, creating compliance risk for your submissions.
Our Solution: Validated. Accepted. Nonanimal.
The OptiSafe EIT is OECD TG 496-accepted — the only fully nonanimal eye irritation test with international regulatory acceptance. IVD EIT and DermaSafe SCT are NIH-funded nonanimal methods validated against OECD reference chemicals. All three replace animal use in ocular and dermal safety testing with human-relevant biochemistry.
Explore Our Test MethodsSpecialized Research Services
Nonanimal ocular, dermal, and biochemical research across eight human tissue compartments: skin, ocular, hepatic, pulmonary, intestinal, renal, neuronal, and cardiac, using both established cell lines and primary human cells.
Ophthalmic & OcularOcular Studies
Mechanistic efficacy and dose-response toxicity profiling of candidate ophthalmic compounds, eye area cosmetics, and ocular-contact materials using both validated cell-free macromolecular platforms and human ocular cell-based models. Delivers quantitative irritation classification, injury-severity scoring, and cytotoxicity data.
Skin & TopicalDermal Studies
Comprehensive cytotoxicity, corrosion, and irritation assessment of active pharmaceutical ingredients, excipients, and topical formulations using both cell-free InChemico™ biochemical platforms and human cell-based models, including primary keratinocytes, fibroblasts, and reconstructed tissue.
Custom PlatformsAssay Development
Custom design and validation of in chemico, in vitro, ex vivo and biochemical assay platforms.
Standardized Test Services
Developed by Lebrun Labs
The OptiSafe Eye Irritation Test™ (OptiSafe EIT™)
Eye irritation test for regulatory use (OECD 496). The OptiSafe EIT™ is highly sensitive and the best choice for eye area cosmetics and personal care products, except those containing metal oxides (e.g., zinc oxide, metals in eyeshadows), which should be tested with IVD EIT. Kits are available at inchemico.co.
Developed by Lebrun Labs
Now Available!The In Vitro Depth of Injury™ Eye Irritation Test (IVD EIT™)
The only nonanimal test able to discriminate "Eye Protection Required" vs. no labeling required, distinguishing Globally Harmonized System (GHS) categories NC and 2B from 2A and 1. Broad sensitivity covers the full product spectrum, from cosmetics to strong industrial solvents. High mechanistic relevance makes it a strong choice for ocular drug studies.
Developed by Lebrun Labs
Now Available!The DermaSafe Skin Corrosion Test™ (DermaSafe SCT™)
The DermaSafe SCT™ is a nonanimal test that can be used to classify the dermal corrosivity of consumer products and industrial chemicals. Results are often used to support Globally Harmonized System (GHS) safety labeling, product documentation and assign Department of Transportation (DOT) packing groups. The test evaluates the extent of dermal corrosion and relates this to regulatory classifications.
Submit a Sample for Testing
IVD EIT™ and DermaSafe SCT™ are available now. Get a real-time cost estimate on the submission form before you submit. Volume and multi-test discounts apply automatically.
In Vitro Depth of Injury™ Eye Irritation Test (IVD EIT™)
Ocular Irritancy, GHS class prediction, EPA class prediction, mechanistic insights
The only nonanimal test able to discriminate "Eye Protection Required" vs. no labeling required, distinguishing GHS categories NC and 2B from 2A and 1. Broad sensitivity covers the full product spectrum, from cosmetics to strong industrial solvents.
Volume discounts: 20% for 3–9 samples · 30% for 10+ · 25% multi-test discount stacks
DermaSafe Skin Corrosion Test™ (DermaSafe SCT™)
GHS 1A · 1B+1C · Not Corrosive; DOT Packing Group Assignment
A nonanimal in chemico test for classifying dermal corrosives. Supports GHS Category 1A / 1B+1C / Not Corrosive classification and DOT packing group assignment. Shelf-stable, rapid, high-throughput. Patent pending (WO2024177860A1).
Volume discounts: 20% for 3–9 samples · 30% for 10+ · 25% multi-test discount stacks
How It Works
Submit the form
List each material by name and ID/lot number, select tests, choose a payment method, and agree to terms. You receive a reference number instantly.
Ship your samples
Send 2 g or 2 mL per test per sample to our Anaheim, CA lab. Email your tracking number and reference number to [email protected].
Payment & intake
An invoice is issued on sample receipt. Work begins once payment is confirmed. PO accounts available; contact [email protected].
Receive your report
A full GHS classification report with raw data, histopathology (IVD EIT), and regulatory summary is delivered by email.
Ship to: Lebrun Labs LLC · 3301 E. Miraloma Ave., Suite 194, Anaheim, CA 92806 | Attn: Test Services
Run these validated tests in your own lab. OptiSafe and DermaSafe kits available through InChemico.
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