Publications, Abstracts & Patents
Resources
Peer-reviewed publications, conference abstracts, and patents from Lebrun Labs on human-relevant, nonanimal safety testing methods.
Peer-Reviewed Publications
Original research published in scientific journals. Click any title to read the full abstract, plain-language summary, and source links.
Evaluation of a New In Chemico Skin Corrosion Test
Toxicology In Vitro, Vol. 100, 2024
Read Abstract & SummaryAscorbic acid specifically reduces the misclassification of nonirritating reactive chemicals in the OptiSafe™ macromolecular eye irritation test
Toxicology In Vitro, Vol. 80, 2022
Read Abstract & SummaryModeling the antioxidant properties of the eye reduces the false-positive rate of a nonanimal eye irritation test (OptiSafe)
Toxicology In Vitro, Vol. 76, 2021
Read Abstract & SummarySame-chemical comparison of nonanimal eye irritation test methods: BCOP, EpiOcular™, ICE, Ocular Irritection®, OptiSafe™, and STE
Toxicology In Vitro, Vol. 72, 2021
Read Abstract & SummaryAn in vitro depth of injury prediction model for a histopathologic classification of EPA and GHS eye irritants
Toxicology In Vitro, Vol. 61, 2019
Read Abstract & SummaryConference Abstracts
Presentations and meeting abstracts from scientific conferences. Click any title for the full summary and service context.
Society of Toxicology Annual Meeting: Further Optimization of the OptiSafe™ Nonanimal Test Method
Protocol optimizations expanding OptiSafe™ accuracy across organic solvents, solids, and complex mixtures.
Read Full SummarySociety of Toxicology Annual Meeting: Repeatability of a Depth of Injury Test Method for the Classification of Eye Irritants
Within-laboratory repeatability data supporting the IVD EIT as a reproducible, regulatorily-defensible method.
Read Full SummarySociety of Toxicology Annual Meeting: An Improved Version of the OptiSafe™ Test with High Specificity
Improved OptiSafe™ protocol achieving higher specificity than the Draize test, with fewer false positives for safe ingredients.
Read Full SummarySummer School on Innovative Approaches in Science: An Improved Version of the OptiSafe™ Test with High Specificity
Mechanistic rationale for OptiSafe™ design, presented at an international forum on innovative approach methodologies.
Read Full SummarySociety of Toxicology Annual Meeting: Prevalidation of the OptiSafe™ Ocular Irritation Assay for the Detection of Ocular Corrosives
Prevalidation data demonstrating OptiSafe™ reliability for detecting GHS Category 1 ocular corrosives without animal tissue.
Read Full SummarySociety of Toxicology Annual Meeting: Classification of EPA Ocular Irritants and Non-Irritants by the OptiSafe™ Test Method of Mixtures
OptiSafe™ performance on formulated mixtures across all four EPA eye irritation toxicity categories.
Read Full SummaryPatents
Proprietary intellectual property developed by Lebrun Labs. Available for licensing.
Eyewash Formulation
United States Patent and Trademark Office
Novel eyewash formulation engineered to minimize ocular irritation during emergency eye flushing, with applications in workplace safety and ophthalmic irrigation products.
View Patent DetailsQuestions About Our Methods?
Our scientific team is available to discuss test method selection, regulatory strategy, and contract research options for your specific application.
Contact Our Science TeamResearch reported in this publication was supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number SB1ES038803. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Research reported in this publication was supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number SB1ES025501. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Research reported in this publication was supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number R44ES036065. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.