Patent Granted · US12521367B2OECD TG 496NIH/NIEHS SBIR R44ES025501No Animal Components

OptiSafe™ Eye Irritation Test

The only OECD TG 496-validated, fully nonanimal eye irritation test with patented human tear chemistry. Zero false negatives. Results in under 24 hours.

OptiSafe™ EIT test kit — reagent vials and laboratory equipment

About the OptiSafe™ EIT

The OptiSafe™ Eye Irritation Test (OS EIT) macromolecular test matrix is composed of plant-derived proteins, lipids, and nucleotides — no animal ingredient or component of any kind. The method measures the extent of damage to the macromolecular matrix upon exposure to a test chemical, and the measured extent of macromolecular damage is used to predict the toxicity of the tested chemical to the eye.

  • Validated with international regulatory acceptance (OECD Test Guideline 496)
  • True nonanimal eye irritation test — no animal component of any kind
  • Rapid turnaround: quantitative results in less than 24 hours
  • 100% sensitivity — no false negatives for non-irritant vs. rest discrimination
  • Patented tear chemistry reduces false positive rate to lowest of any nonanimal test
100%Sensitivity
< 24 hTurnaround
NoneAnimal Components
496OECD TG

Pricing

Per-sample pricing. Volume discounts apply automatically. Contact us for multi-project or annual contract rates.

QuantityUnit Price
1 sample$2,400
2–3 samples$2,200
4+ samples$2,100

Ready to submit samples?

Use our online inquiry form or contact our team directly.

Research reported in this publication was supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number SB1ES025501. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

The Science Behind OptiSafe™

Expand any topic below for peer-reviewed detail on mechanism, validation data, regulatory context, and NIH funding.

Ready to run OptiSafe™ on your formulation?

OECD TG 496-compliant results delivered in under 24 hours. No animal components. Accepted by U.S. EPA, ECHA, Health Canada, and regulators across Asia-Pacific.

Patent US12521367B2OECD TG 496 ValidatedNIH/NIEHS SBIR Funded100% Sensitivity